Androgenic & Anabolic Dosage

Jeg tok å hentet dette over fra Svensk side, håper ingen blir sure! Men tenkte det kunne være greit å ha på den norske siden og, postet først av R-A-W.

Enjoy

Compound:-----------------------------------------------------------------Androgenic------Anabolic
1-testosterone-----------------------------------------------------------------100--------------200
Anabolicum Vister(Quinbolone)(oral Boldenone)----------------------------50---------------100
Anadrol 50(Oxymetholone)----------------------------------------------------45---------------320
Anadur(Nandrolone Hexyloxyphenylpropionate)-----------------------------37--------------125
Anatrofin(Stenbolone Acetate)--------------------------------------------107-144---------267-332
Anavar(Oxandrolone)----------------------------------------------------------24------------322-630
Andractim(Dihydrotestosteron)---------------------------------------------30-260----------60-220
Andriol(testosterone Undecanoate)------------------------------------------100--------------100
Androderm(testosterone)-----------------------------------------------------100--------------100
Androgel(testosterone)--------------------------------------------------------100--------------100
Boldabol(Boldenone Acetate)---------------------------------------------------50--------------100
Cheque Drops(Mibolerone)---------------------------------------------------1,800------------4,100
Danocrine(Danazol)--------------------------------------------------------------37--------------125
Deca-Durabolin - nandrolone decanoate---------------------------------------37--------------125
Deposterona(testosterone Blend)---------------------------------------------100--------------100
Dianabol(Methandrostenolone)-----------------------------------------------40-60----------90-210
Dimethyltrienolone------------------------------------------------------------10,000+-------10,000+
Dinandrol(Nandrolone Blend)----------------------------------------------------37--------------125
Durabolin(NPP - Nandrolone PhenylPropionate - )-----------------------------37--------------125
Dynabol(Nandrolone Cypionate)-------------------------------------------------37--------------125
Equipoise(Boldenone Undecylenate)--------------------------------------------50--------------100
Esiclene(Formebolone)-----------------------------------------------------------No Data Available
Genabol(Norbolethone)----------------------------------------------------------17---------------350
Halotestin(Fluoxymesterone)---------------------------------------------------850------------1,900
Hydroxytestosterone-------------------------------------------------------------25---------------65
Laurabolin(Nandrolone Laurate)------------------------------------------------37--------------125
Madol(Desoxymethyltestosterone)---------------------------------------------187------------1,200
Masteron(Drostanolone Propionate)------------------------------------------25-40---------62-130
Megagrisevit-Mono(Clostebol Acetate)----------------------------------------25----------------46
MENT(Methylnortestosterone Acetate)----------------------------------------650------------2,300
Mestanolone--------------------------------------------------------------------78-254------------107
Methandriol(Mythelandrostenediol)-------------------------------------------30-60-----------20-60
Methyl-1-testosterone--------------------------------------------------------100-220----910-1,600
Methyldienolone---------------------------------------------------------------200-300---------1,000
Methylhydroxynandrolone(MHN)-------------------------------------------------281-----------1304
Methyltestosterone-------------------------------------------------------------94-130------115-150
Metribolone(Methyltrienolone)-----------------------------------6,000-7,000------12,000-30,000
Miotolan(Furazabol)--------------------------------------------------------------73-94------270-330
Myagen(Bolasterone)--------------------------------------------------------------300------------575
Nilevar(Norethandrolone)--------------------------------------------------------22-55------100-200
Omnadren(testosterone Blend)---------------------------------------------------100------------100
Orabolin(Ethylestrenol)----------------------------------------------------------20-400-----200-400
Oral Turinabol----------------------------------------------------------------------None---------100+
Oranabol(Oxymesterone)-----------------------------------------------------------50-----------330
Orgasteron(Normethandrolone)-----------------------------------------------325-580-----110-125
Parabolan(trenbolone Hexahydrobenzycarbonate)-------------------------------500----------500
Primobolan(Methenolone Acetate)----------------------------------------------44-57-----------88
Primobolan Depot(Methenolone Enanthate)------------------------------------44-57-----------88
Prostanozol--------------------------------------------------------------------------n/a----------n/a
Protabol(Thiomesterone)-----------------------------------------------------------61-----------456
Proviron(Mesterolone)-----------------------------------------------------------30-40------100-150
Sanabolicum(Nandrolone Cyclohexylpropionate)---------------------------------37-----------125
Steranabol Ritardo(Oxabolone Cypionate)-------------------------------------20-60--------50-90
Superdrol(Methyldrostanolone)---------------------------------------------------400-------------20
Sustanon 100 & 250----------------------------------------------------------------100-----------100
Synovex(testosterone Propionate & Estradiol)----------------------------------100-----------100
test 400------------------------------------------------------------------------------100-----------100
test Enanthate/Cypionate/Propionate/testosterone suspension & Blends---100-----------100
THG(Tetrahydrogestrinone)------------------------------------------------------No Data Available
trenbolone Acetate/Enanthate & Blends------------------------------------------500-----------500
Winstrol(Stanozolol)------------------------------------------------------------------30-----------320


Anabolic and Androgenic

The anabolic:androgenic ratios for steroids and prohormones are often quoted, but what do they mean?

In the 1960s when the majority of steroid research was undertaken, before steroids became a dirty word, the goal of the researchers was to develop steroids that could increase muscle mass (in cancer patients, burn victims, those with wasting diseases etc.) without also causing the secondary male sex characteristics that natural steroids like testosterone can cause (like increased facial hair, deeper voice, enlarged clitoris in females). They were trying to develop steroids that were anabolic without being androgenic.

Of course medical science has pesky moral objections to testing unknown substances on human test subjects (even though these days gymrats are willing to queue round the block to take the latest untested designer steroid compounds), so a system of testing was developed on rats.


The Hershberger Assay

The steroids were administered to rats either orally (through a gavage tube) or by injection. The rats were sacrificed after the experiment (which is known as the Hershberger Assay), and the increase in the weights of the levator ani, seminal vesicles, and ventral prostate, were recorded and compared to a standard such as testosterone (if by injection) or methyl testosterone (if administered orally).

The levator ani is the "tail-wagging" muscle in animals, and as such any increase in weight provides a reasonable estimate of the anabolic nature of the compound.
The seminal vesicles and the ventral prostate are both involved in the production of semen, and are androgen-sensitive tissues, that is they grow when androgenic compounds are administered.

By using these markers, the scientists tried to make compounds that had a high anabolic value (as measured by the levator ani, or L.A) and low androgenic value (as measured by seminal vesicles, S.V., and ventral prostate, V.P.).


Viva la Vida

In the late 1960s a young scientist called Julius Vida spent a long time collecting and reviewing all the available data on steroids that had been published so far. In 1969 he published a book called "Androgens and Anabolic Agents - Chemistry and Pharmacology". The first part of this book was a discussion on the metabolism, and structure and activity relationships of these compounds, while the second part listed 666 steroids, organised by structure, and for each he listed the steroidal nomenclature (the chemical name for the drug), a structural diagram of the compound, and the anabolic and androgenic values compared to a standard along with the method of administration used to determine them (i.e. oral or subcutaneous injection). He also provides a reference number that refers to a bibliography to show which study the figures were originally published in.

These figures form the basis of the anabolic:androgenic ratios we see quoted today.


In Detail

Here's an example of one of the compounds listed in Vida's book. I've added some labels to make it a bit more clear.

Image

We aren't concerned about the serial, nomenclature or chemical structure at the present time. Looking at the method of administration, for the top row it is empty (meaning that the figures on that row were the result of subcutaneous injection) and on the second row it says oral, meaning that the steroid was orally administered to arrive at the figures on that row.

Since this compound is methylepithiostanol, more commonly known as the prohormone/designer steroid "epi" (or by the trade names epistane and havoc), and is currently only available in caps for oral administration, we should only concern ourselves with the figures on the second row - those arrived at by oral admin.

Those figures are given as ventral prostate/seminal vesicles: 91, levator ani: 1100, and the basis of comparison is given as 17a-MT (methyltestosterone).
This gives it an anabolic:androgenic ratio of 1100:91 (compared to methyl test). Methyl test is assumed to be 100:100 for the purposes of this comparison. What this means is that epi is 11 times more anabolic (1100%) and roughly as androgenic (91% as androgenic) as methyl test (by oral administration to rats).


In Conclusion

While these figures do not translate literally to their effects on humans, they tend to give a reasonable impression of the nature of a given steroid. In medical science, these would be the first tests they would do on a newly synthesized compound to determine it's initial viability. If it proved effective, and had a strong dissociation of anabolic and androgenic effects, it may have progressed to further testing and eventually human trials.

Many of the compounds available on the prohormone and designer steroid market today never progressed beyond this initial animal testing stage, and some of them are entirely novel compounds with no scientific testing undertaken at all.

One of the problems with the A:A figures is that there are large discrepancies between testing conditions from paper to paper, and compounds are often tested at different doses. The comparison I generally use is that methyl tren is ~10,000% (100 times) more anabolic than methyl test. That doesn't mean it makes you 100 times bigger, it means you have to dose it 100 times lower to achieve comparable results.